To study the effects of Zabol wastewater treated with two kinds of fertilizer (manure and chemical fertilizer) application vs use of ordinary water on grain yield and yield components in corn (KoSc704) a field experiment was conducted at the University of Zabol, Iran during 2007 growing season. The statistical plan selected was a split plot one of three replications. The treatments were comprised of two kinds of irrigation water (W1= well drawn water, and W2= domestic wastewater) as main plots and five levels of fertilizer (F1=control, F2= manure: 30 tons.ha-1, F3= manure: 15 tons.ha-1, F4= NPK: 350, 200 and 100 kgha-1 and F5=NPK: 175, 100 and 50 kgha-1) as sub plots. Results indicated that irrigation with wastewater significantly increased grain yield of corn as compared with use of ordinary (normal) water. Also it was shown that wastewater had positive significant influence on grain yield and on all yield components with the most effect on 1000-seed weight. Among the fertilizer treatments, F4, in all situations, exerted the most effect on the grain yield and yield components increasing them. Application of wastewater had a significant effect on two osmotic components (proline and carbohydrate) increasing their contents in green leaf tissue. Among the fertilizer treatments, F4 positively affected the contents of these two components the most.